Huntington's Disease Quiz: Test Your Knowledge

🧠 Quick Study Guide

• 🧬 Genetics: Huntington's Disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the $HTT$ gene.
• 🔁 CAG Repeats: The mutation involves an expansion of CAG repeats within the $HTT$ gene. Normal individuals have fewer than 36 repeats, while those with HD typically have 40 or more.
• Symptoms: HD is characterized by a triad of motor, cognitive, and psychiatric symptoms.
• 🕺 Motor Symptoms: Chorea (involuntary, jerky movements), rigidity, and impaired coordination are common motor manifestations.
• 🧠 Cognitive Symptoms: Cognitive decline, including difficulties with executive function, memory, and attention, occurs in HD.
• 💔 Psychiatric Symptoms: Depression, anxiety, irritability, and obsessive-compulsive behaviors are frequently observed in individuals with HD.
• 🕰️ Progression: The disease typically progresses over 10-20 years, leading to significant disability and ultimately death.
• 💊 Treatment: There is no cure for HD; treatment focuses on managing symptoms and providing supportive care. Medications can help control chorea and address psychiatric symptoms.

🧪 Practice Quiz

1. Which gene is primarily associated with Huntington's Disease?
   1. A) $APP$
   2. B) $HTT$
   3. C) $SOD1$
   4. D) $MAPT$
2. What type of genetic mutation causes Huntington's Disease?
   1. A) Point mutation
   2. B) Frameshift mutation
   3. C) Triplet repeat expansion
   4. D) Deletion
3. What is the primary motor symptom associated with Huntington's Disease?
   1. A) Akinesia
   2. B) Chorea
   3. C) Bradykinesia
   4. D) Dystonia
4. Which cognitive function is commonly affected in Huntington's Disease?
   1. A) Visual perception
   2. B) Language comprehension
   3. C) Executive function
   4. D) Spatial reasoning
5. Which of the following is a common psychiatric symptom in Huntington's Disease?
   1. A) Euphoria
   2. B) Delusions of grandeur
   3. C) Depression
   4. D) Lack of emotion
6. How many CAG repeats are typically found in individuals with Huntington's Disease?
   1. A) Less than 20
   2. B) 20-35
   3. C) 36-39
   4. D) 40 or more
7. What is the main focus of treatment for Huntington's Disease?
   1. A) Curing the disease
   2. B) Slowing disease progression
   3. C) Managing symptoms
   4. D) Gene therapy